CGB1

The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]

Description

Chorionic gonadotropin subunit beta 1

Tissue specificity

Group enriched (pancreas, pituitary gland)

Subcell location

Cytosol

Predicted location

Intracellular, Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins

Chromosome

19 (49035569 - 49036895)

Ensembl ID

ENSG00000267631  (ver. 103.38)

Orthologs

-

UniProt

A6NKQ9

neXtProt

NX_A6NKQ9

Human splice variants

Protein structure