ADORA3

This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]

Description

Adenosine A3 receptor

Tissue specificity

Tissue enhanced (brain)

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

1 (111499429 - 111503633)

Ensembl ID

ENSG00000282608  (ver. 103.38)

Orthologs

Mouse Adora3: ENSMUSG00000000562

UniProt

P0DMS8

neXtProt

NX_P0DMS8

Human splice variants
Mouse splice variants

Protein structure