Antibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- AF1488 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal MMP-2 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse and rat MMP-2 in direct ELISAs and Western blots. In direct ELISAs, less than 40% cross-reactivity with recombinant human MMP-2 is observed and less than 1% cross-reactivity with recombinant mouse (rm) MMP-3 and rmMMP-9 is observed.
- Reactivity
- Mouse, Rat
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references ATRQβ-001 Vaccine Prevents Experimental Abdominal Aortic Aneurysms.
Tea Polysaccharide Prevents Colitis-Associated Carcinogenesis in Mice by Inhibiting the Proliferation and Invasion of Tumor Cells.
Chemopreventive Potential of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside on the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colorectal Cancer in Rats.
Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression.
Smooth muscle cell-specific Tgfbr1 deficiency attenuates neointimal hyperplasia but promotes an undesired vascular phenotype for injured arteries.
Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
The ω-3 polyunsaturated fatty acid, eicosapentaenoic acid, attenuates abdominal aortic aneurysm development via suppression of tissue remodeling.
Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy.
KLF4 regulates abdominal aortic aneurysm morphology and deletion attenuates aneurysm formation.
G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
Site-specific expression of gelatinolytic activity during morphogenesis of the secondary palate in the mouse embryo.
Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice.
Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet.
High dietary intake of retinol leads to bone marrow hypoxia and diaphyseal endosteal mineralization in rats.
Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans.
Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease.
Genetic deficiency of heme oxygenase-1 impairs functionality and form of an arteriovenous fistula in the mouse.
Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling.
A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.
Characterization of lymphangiogenesis in a model of adult skin regeneration.
Expression of matrix metalloproteinases subsequent to urogenital Chlamydia muridarum infection of mice.
Zhang H, Liao M, Cao M, Qiu Z, Yan X, Zhou Y, Wu H, Wang Y, Zheng J, Ding J, Wang M, Liao Y, Chen X
Journal of the American Heart Association 2019 Sep 17;8(18):e012341
Journal of the American Heart Association 2019 Sep 17;8(18):e012341
Tea Polysaccharide Prevents Colitis-Associated Carcinogenesis in Mice by Inhibiting the Proliferation and Invasion of Tumor Cells.
Liu LQ, Li HS, Nie SP, Shen MY, Hu JL, Xie MY
International journal of molecular sciences 2018 Feb 8;19(2)
International journal of molecular sciences 2018 Feb 8;19(2)
Chemopreventive Potential of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside on the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colorectal Cancer in Rats.
Lin CL, Jeng JH, Wu CC, Hsieh SL, Huang GC, Leung W, Lee CT, Chen CY, Lee CH
BioMed research international 2017;2017:3634915
BioMed research international 2017;2017:3634915
Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression.
Chen PC, Tang CH, Lin LW, Tsai CH, Chu CY, Lin TH, Huang YL
Journal of hematology & oncology 2017 Jan 25;10(1):33
Journal of hematology & oncology 2017 Jan 25;10(1):33
Smooth muscle cell-specific Tgfbr1 deficiency attenuates neointimal hyperplasia but promotes an undesired vascular phenotype for injured arteries.
Liao M, Yang P, Wang F, Berceli SA, Ali YH, Chan KL, Jiang Z
Physiological reports 2016 Dec;4(23)
Physiological reports 2016 Dec;4(23)
Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
Dohi K, Kraemer BC, Erickson MA, McMillan PJ, Kovac A, Flachbartova Z, Hansen KM, Shah GN, Sheibani N, Salameh T, Banks WA
PloS one 2014;9(9):e108034
PloS one 2014;9(9):e108034
The ω-3 polyunsaturated fatty acid, eicosapentaenoic acid, attenuates abdominal aortic aneurysm development via suppression of tissue remodeling.
Wang JH, Eguchi K, Matsumoto S, Fujiu K, Komuro I, Nagai R, Manabe I
PloS one 2014;9(5):e96286
PloS one 2014;9(5):e96286
Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy.
O'Neal WT, Griffin WF, Kent SD, Faiz F, Hodges J, Vuncannon J, Virag JA
Frontiers in physiology 2014;5:132
Frontiers in physiology 2014;5:132
KLF4 regulates abdominal aortic aneurysm morphology and deletion attenuates aneurysm formation.
Salmon M, Johnston WF, Woo A, Pope NH, Su G, Upchurch GR Jr, Owens GK, Ailawadi G
Circulation 2013 Sep 10;128(11 Suppl 1):S163-74
Circulation 2013 Sep 10;128(11 Suppl 1):S163-74
G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
Raghuwanshi SK, Smith N, Rivers EJ, Thomas AJ, Sutton N, Hu Y, Mukhopadhyay S, Chen XL, Leung T, Richardson RM
Journal of immunology (Baltimore, Md. : 1950) 2013 May 15;190(10):5329-36
Journal of immunology (Baltimore, Md. : 1950) 2013 May 15;190(10):5329-36
Site-specific expression of gelatinolytic activity during morphogenesis of the secondary palate in the mouse embryo.
Gkantidis N, Blumer S, Katsaros C, Graf D, Chiquet M
PloS one 2012;7(10):e47762
PloS one 2012;7(10):e47762
Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice.
Xue M, Dervish S, Harrison LC, Fulcher G, Jackson CJ
The Journal of biological chemistry 2012 May 11;287(20):16356-64
The Journal of biological chemistry 2012 May 11;287(20):16356-64
Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet.
Lau WL, Leaf EM, Hu MC, Takeno MM, Kuro-o M, Moe OW, Giachelli CM
Kidney international 2012 Dec;82(12):1261-70
Kidney international 2012 Dec;82(12):1261-70
High dietary intake of retinol leads to bone marrow hypoxia and diaphyseal endosteal mineralization in rats.
Lind T, Lind PM, Jacobson A, Hu L, Sundqvist A, Risteli J, Yebra-Rodriguez A, Larsson S, Rodriguez-Navarro A, Andersson G, Melhus H
Bone 2011 Mar 1;48(3):496-506
Bone 2011 Mar 1;48(3):496-506
Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans.
Meissburger B, Stachorski L, Röder E, Rudofsky G, Wolfrum C
Diabetologia 2011 Jun;54(6):1468-79
Diabetologia 2011 Jun;54(6):1468-79
Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease.
Pai A, Leaf EM, El-Abbadi M, Giachelli CM
The American journal of pathology 2011 Feb;178(2):764-73
The American journal of pathology 2011 Feb;178(2):764-73
Genetic deficiency of heme oxygenase-1 impairs functionality and form of an arteriovenous fistula in the mouse.
Juncos JP, Tracz MJ, Croatt AJ, Grande JP, Ackerman AW, Katusic ZS, Nath KA
Kidney international 2008 Jul;74(1):47-51
Kidney international 2008 Jul;74(1):47-51
Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling.
Bujak M, Dobaczewski M, Chatila K, Mendoza LH, Li N, Reddy A, Frangogiannis NG
The American journal of pathology 2008 Jul;173(1):57-67
The American journal of pathology 2008 Jul;173(1):57-67
A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.
Rafei M, Wu JH, Annabi B, Lejeune L, François M, Galipeau J
Blood 2007 Mar 1;109(5):2234-42
Blood 2007 Mar 1;109(5):2234-42
Characterization of lymphangiogenesis in a model of adult skin regeneration.
Rutkowski JM, Boardman KC, Swartz MA
American journal of physiology. Heart and circulatory physiology 2006 Sep;291(3):H1402-10
American journal of physiology. Heart and circulatory physiology 2006 Sep;291(3):H1402-10
Expression of matrix metalloproteinases subsequent to urogenital Chlamydia muridarum infection of mice.
Ramsey KH, Sigar IM, Schripsema JH, Shaba N, Cohoon KP
Infection and immunity 2005 Oct;73(10):6962-73
Infection and immunity 2005 Oct;73(10):6962-73
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
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- Experimental details
- MMP-2 in Mouse Thymus. MMP-2 was detected in perfusion fixed frozen sections of mouse thymus using Goat Anti-Mouse/ Rat MMP-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1488) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.