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IFIH1
Interferon induced with helicase C domain 1Hlcd, IDDM19, MDA-5, MDA5
IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response. Sensing RNA length and secondary structure, MDA5 binds dsRNA oligonucleotides with a modified DExD/H-box helicase core and a C-terminal domain, thus leading to a proinflammatory response that includes interferons. It has been shown that Coronaviruses (CoVs) as well as various other virus families, are capable of evading the MDA5-dependent interferon response, thus impeding the activation of the innate immune response to infection. MDA5 has also been shown to play an important role in enhancing natural killer cell function in malaria infection. In addition to its protective role in antiviral responses, MDA5 has been implicated in autoimmune and autoinflammatory diseases such as type 1 diabetes, systemic lupus erythematosus, and Aicardi-Goutieres syndrome [provided by RefSeq, Jul 2020]
Top validated antibodies |
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| Invitrogen Antibodies |  700360 |
5 references | Monoclonal |
WB
ICC
IHC
FC
OA
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| Proteintech Group | 21775-1-AP |
20 references | Polyclonal |
WB
EL
IP
IHC
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| antibodies-online | ABIN500266 |
6 references | Polyclonal |
WB
EL
ICC
IHC
|
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| Novus Biologicals | NB110-1244 |
8 references | Polyclonal |
WB
EL
IHC
|
|
| GeneTex | GTX31304 |
Polyclonal |
WB
EL
ICC
IHC
|
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