CHAF1B

Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. [provided by RefSeq, Jul 2008]

Description

Chromatin assembly factor 1 subunit B

Tissue specificity

Tissue enhanced (skeletal muscle)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

21 (36385392 - 36419015)

Ensembl ID

ENSG00000159259  (ver. 103.38)

Orthologs

Mouse Chaf1b: ENSMUSG00000022945

UniProt

Q13112

neXtProt

NX_Q13112

Human splice variants
Mouse splice variants

Protein structure