P2RX6

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]

Description

Purinergic receptor P2X 6

Tissue specificity

Group enriched (brain, skeletal muscle, tongue)

Subcell location

Nucleoli, Cytosol

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

22 (21009808 - 21028830)

Ensembl ID

ENSG00000099957  (ver. 103.38)

Orthologs

Mouse P2rx6: ENSMUSG00000022758

UniProt

O15547

neXtProt

NX_O15547

Human splice variants
Mouse splice variants

Protein structure