Antibody data
- Antibody Data
- Antigen structure
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- Product number
- DCABH-2660 - Provider product page
- Provider
- Creative Diagnostics
- Proper citation
- Creative Diagnostics Cat#DCABH-2660, RRID:AB_2476551
- Product name
- Rabbit Anti-Human A2M monoclonal antibody, clone KN92-52
- Antibody type
- Monoclonal
- Description
- Ï«-2-Macroglobulin (Ï«-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, Ï«-2M was characterized as a pan-proteinase inhibitor that was able to "bait" proteinases into cleaving specific peptide sequences on Ï«-2M. This interaction induces a conformational change in Ï«-2M, thus enabling it to "trap" the proteinase and further inhibit its activity. Subsequently, Ï«-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor ÉÇ (TGFÉÇ) in serum is primarily bound to Ï«-2M, which renders TGFÉÇ inactive. Ï«-2M also binds to IL-6 and, thereby, increases the concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding Ï«-2M are associated with an increased incidence of Alzheimer's Disease (AD), which is consistent with the role of Ï«-2M in mediating the clearance and degradation of A ÉÇ, the major component of ÉÇ-Amyloid deposits accumulated during AD.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- KN92-52
- Vial size
- 100 _l
- Storage
- Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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