PPP1R13B

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]

Description

Protein phosphatase 1 regulatory subunit 13B

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

14 (103733195 - 103847575)

Ensembl ID

ENSG00000088808  (ver. 103.38)

Orthologs

Mouse Ppp1r13b: ENSMUSG00000021285

UniProt

Q96KQ4

neXtProt

NX_Q96KQ4

Human splice variants
Mouse splice variants

Protein structure