APOH

Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS. [provided by RefSeq, Dec 2019]

Description

Apolipoprotein H

Tissue specificity

Tissue enriched (liver)

Subcell location

Golgi apparatus

Predicted location

Intracellular, Secreted to blood

Protein family

Candidate cardiovascular disease genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (66212033 - 66256525)

Ensembl ID

ENSG00000091583  (ver. 103.38)

Orthologs

Mouse Apoh: ENSMUSG00000000049

UniProt

P02749

neXtProt

NX_P02749

Human splice variants
Mouse splice variants

Protein structure