11-7512

antibody from ABEOMICS Inc.
Targeting: SPARC BM-40, ON, ONT
Provider product page for 11-7512

Antibody data

Product number
11-7512 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-SPARC/Osteonectin Antibody
Antibody type
Polyclonal
Description
SPARC (Secreted protein, acidic, cysteine-rich) is a glycoprotein that binds to collagen type I and other proteins in the extracellular matrix. It is involved in normal tissue remodeling as it regulates the deposition of extracellular matrix, and also plays a role in neoplastic transformation. It modulates interactions between tumoral cells and the peri-tumoral stroma. Homozygous mutations in SPARC give rise to severe bone fragility in humans. SPARC negatively regulates glucose metabolism in hepatocellular carcinoma (HCC). Overexpression of SPARC inhibited glucose uptake and lactate product through downregulation of key enzymes of glucose metabolism.
Reactivity
Human
Host
Rabbit
Antigen sequence
A partial length recombinant SPARC/
Osteonectin protein (amino acids 52
-268) was used as the immunogen for
this antibody.
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
SPARC protein structure - 11-7512 shown in red.