Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 11-7512 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-SPARC/Osteonectin Antibody
- Antibody type
- Polyclonal
- Description
- SPARC (Secreted protein, acidic, cysteine-rich) is a glycoprotein that binds to collagen type I and other proteins in the extracellular matrix. It is involved in normal tissue remodeling as it regulates the deposition of extracellular matrix, and also plays a role in neoplastic transformation. It modulates interactions between tumoral cells and the peri-tumoral stroma. Homozygous mutations in SPARC give rise to severe bone fragility in humans. SPARC negatively regulates glucose metabolism in hepatocellular carcinoma (HCC). Overexpression of SPARC inhibited glucose uptake and lactate product through downregulation of key enzymes of glucose metabolism.
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
A partial length recombinant SPARC/
Osteonectin protein (amino acids 52
-268) was used as the immunogen for
this antibody.- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Expression analysis SPARC. Anti-SPARC antibody (11-7512) was used at 2 µg/ml on U87 lysate.