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antibody from antibodies-online
Targeting: ARNT
bHLHe2, HIF-1beta
Western blot
Immunocytochemistry Immunoprecipitation Immunohistochemistry Gel shift Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [34]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- ABIN151037 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) antibody
- Antibody type
- Polyclonal
- Description
- Unpurified
- Reactivity
- Human, Mouse, Rat, Bovine, Sheep
- Host
- Rabbit
- Vial size
- 0.1 mL
- Storage
- Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes.
Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.
Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters.
Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer.
P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells.
Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer.
Progesterone, as well as 17β-estradiol, is important for regulating AHR battery homoeostasis in the rat uterus.
Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function.
Differential distribution of hypoxia-inducible factor 1-beta (ARNT or ARNT2) in mouse substantia nigra and ventral tegmental area.
FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter.
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells.
BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes.
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells.
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.
HIF2α-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells.
High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq.
Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression.
Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures.
Hypoxia-inducible factor-1 drives annexin A2 system-mediated perivascular fibrin clearance in oxygen-induced retinopathy in mice.
Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha.
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.
IFN-γ attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1β.
Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1.
Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.
Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to follicle-stimulating hormone.
Hypoxia-inducible factors in the first trimester human lung.
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.
Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia.
Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running.
Expression and localization of hypoxia-inducible factor-1 subunits in the adult rat epididymis.
Expansion of human SCID-repopulating cells under hypoxic conditions.
Stimulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1alpha messenger RNA expression.
Putative link between transcriptional regulation of IgM expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the aryl hydrocarbon receptor/dioxin-responsive enhancer signaling pathway.
Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides.
Kobayashi M, Morinibu A, Koyasu S, Goto Y, Hiraoka M, Harada H
The FEBS journal 2017 Nov;284(22):3804-3816
The FEBS journal 2017 Nov;284(22):3804-3816
Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.
Grampp S, Schmid V, Salama R, Lauer V, Kranz F, Platt JL, Smythies J, Choudhry H, Goppelt-Struebe M, Ratcliffe PJ, Mole DR, Schödel J
PLoS genetics 2017 Jul;13(7):e1006872
PLoS genetics 2017 Jul;13(7):e1006872
Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters.
Platt JL, Salama R, Smythies J, Choudhry H, Davies JO, Hughes JR, Ratcliffe PJ, Mole DR
EMBO reports 2016 Oct;17(10):1410-1421
EMBO reports 2016 Oct;17(10):1410-1421
Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer.
Grampp S, Platt JL, Lauer V, Salama R, Kranz F, Neumann VK, Wach S, Stöhr C, Hartmann A, Eckardt KU, Ratcliffe PJ, Mole DR, Schödel J
Nature communications 2016 Oct 24;7:13183
Nature communications 2016 Oct 24;7:13183
P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells.
Kraus A, Grampp S, Goppelt-Struebe M, Schreiber R, Kunzelmann K, Peters DJ, Leipziger J, Schley G, Schödel J, Eckardt KU, Buchholz B
Purinergic signalling 2016 Dec;12(4):687-695
Purinergic signalling 2016 Dec;12(4):687-695
Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer.
Salama R, Masson N, Simpson P, Sciesielski LK, Sun M, Tian YM, Ratcliffe PJ, Mole DR
PloS one 2015;10(8):e0134645
PloS one 2015;10(8):e0134645
Progesterone, as well as 17β-estradiol, is important for regulating AHR battery homoeostasis in the rat uterus.
Rataj F, Möller FJ, Jähne M, Hönscheid P, Zierau O, Vollmer G, Kretzschmar G
Archives of toxicology 2015 Mar;89(3):393-404
Archives of toxicology 2015 Mar;89(3):393-404
Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function.
Wong WJ, Richardson T, Seykora JT, Cotsarelis G, Simon MC
The Journal of investigative dermatology 2015 Feb;135(2):454-461
The Journal of investigative dermatology 2015 Feb;135(2):454-461
Differential distribution of hypoxia-inducible factor 1-beta (ARNT or ARNT2) in mouse substantia nigra and ventral tegmental area.
Dela Cruz JA, Schmidt-Kastner R, Stevens JA, Steinbusch HW, Rutten BP
Journal of chemical neuroanatomy 2014 Nov;61-62:64-71
Journal of chemical neuroanatomy 2014 Nov;61-62:64-71
FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter.
Zhu J, Jiang X, Chehab FF
Journal of lipid research 2014 Mar;55(3):431-42
Journal of lipid research 2014 Mar;55(3):431-42
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells.
Pawlus MR, Wang L, Hu CJ
Oncogene 2014 Mar 27;33(13):1670-9
Oncogene 2014 Mar 27;33(13):1670-9
BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes.
Sena JA, Wang L, Hu CJ
Molecular and cellular biology 2013 Oct;33(19):3849-63
Molecular and cellular biology 2013 Oct;33(19):3849-63
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells.
Schito L, Rey S, Tafani M, Zhang H, Wong CC, Russo A, Russo MA, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2012 Oct 2;109(40):E2707-16
Proceedings of the National Academy of Sciences of the United States of America 2012 Oct 2;109(40):E2707-16
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.
Schödel J, Bardella C, Sciesielski LK, Brown JM, Pugh CW, Buckle V, Tomlinson IP, Ratcliffe PJ, Mole DR
Nature genetics 2012 Mar 11;44(4):420-5, S1-2
Nature genetics 2012 Mar 11;44(4):420-5, S1-2
HIF2α-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells.
Koizume S, Ito S, Miyagi E, Hirahara F, Nakamura Y, Sakuma Y, Osaka H, Takano Y, Ruf W, Miyagi Y
Nucleic acids research 2012 Jul;40(12):5389-401
Nucleic acids research 2012 Jul;40(12):5389-401
High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq.
Lo R, Matthews J
Toxicological sciences : an official journal of the Society of Toxicology 2012 Dec;130(2):349-61
Toxicological sciences : an official journal of the Society of Toxicology 2012 Dec;130(2):349-61
Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression.
Jantsch J, Wiese M, Schödel J, Castiglione K, Gläsner J, Kolbe S, Mole D, Schleicher U, Eckardt KU, Hensel M, Lang R, Bogdan C, Schnare M, Willam C
Journal of leukocyte biology 2011 Sep;90(3):551-62
Journal of leukocyte biology 2011 Sep;90(3):551-62
Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures.
Stejskalova L, Vecerova L, Peréz LM, Vrzal R, Dvorak Z, Nachtigal P, Pavek P
Toxicological sciences : an official journal of the Society of Toxicology 2011 Sep;123(1):26-36
Toxicological sciences : an official journal of the Society of Toxicology 2011 Sep;123(1):26-36
Hypoxia-inducible factor-1 drives annexin A2 system-mediated perivascular fibrin clearance in oxygen-induced retinopathy in mice.
Huang B, Deora AB, He KL, Chen K, Sui G, Jacovina AT, Almeida D, Hong P, Burgman P, Hajjar KA
Blood 2011 Sep 8;118(10):2918-29
Blood 2011 Sep 8;118(10):2918-29
Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha.
Lin Q, Cong X, Yun Z
Molecular cancer research : MCR 2011 Jun;9(6):757-65
Molecular cancer research : MCR 2011 Jun;9(6):757-65
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.
Schödel J, Oikonomopoulos S, Ragoussis J, Pugh CW, Ratcliffe PJ, Mole DR
Blood 2011 Jun 9;117(23):e207-17
Blood 2011 Jun 9;117(23):e207-17
IFN-γ attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1β.
Glover LE, Irizarry K, Scully M, Campbell EL, Bowers BE, Aherne CM, Kominsky DJ, MacManus CF, Colgan SP
Journal of immunology (Baltimore, Md. : 1950) 2011 Feb 1;186(3):1790-8
Journal of immunology (Baltimore, Md. : 1950) 2011 Feb 1;186(3):1790-8
Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1.
Gimm T, Wiese M, Teschemacher B, Deggerich A, Schödel J, Knaup KX, Hackenbeck T, Hellerbrand C, Amann K, Wiesener MS, Höning S, Eckardt KU, Warnecke C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Nov;24(11):4443-58
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Nov;24(11):4443-58
Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.
Chung CY, Koprich JB, Siddiqi H, Isacson O
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Mar 18;29(11):3365-73
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Mar 18;29(11):3365-73
Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to follicle-stimulating hormone.
Alam H, Weck J, Maizels E, Park Y, Lee EJ, Ashcroft M, Hunzicker-Dunn M
Endocrinology 2009 Feb;150(2):915-28
Endocrinology 2009 Feb;150(2):915-28
Hypoxia-inducible factors in the first trimester human lung.
Groenman F, Rutter M, Caniggia I, Tibboel D, Post M
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007 Apr;55(4):355-63
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007 Apr;55(4):355-63
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.
Khan Z, Michalopoulos GK, Stolz DB
The American journal of pathology 2006 Oct;169(4):1251-69
The American journal of pathology 2006 Oct;169(4):1251-69
Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia.
Franco M, Man S, Chen L, Emmenegger U, Shaked Y, Cheung AM, Brown AS, Hicklin DJ, Foster FS, Kerbel RS
Cancer research 2006 Apr 1;66(7):3639-48
Cancer research 2006 Apr 1;66(7):3639-48
Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running.
Malm C, Sjödin TL, Sjöberg B, Lenkei R, Renström P, Lundberg IE, Ekblom B
The Journal of physiology 2004 May 1;556(Pt 3):983-1000
The Journal of physiology 2004 May 1;556(Pt 3):983-1000
Expression and localization of hypoxia-inducible factor-1 subunits in the adult rat epididymis.
Palladino MA, Powell JD, Korah N, Hermo L
Biology of reproduction 2004 Apr;70(4):1121-30
Biology of reproduction 2004 Apr;70(4):1121-30
Expansion of human SCID-repopulating cells under hypoxic conditions.
Danet GH, Pan Y, Luongo JL, Bonnet DA, Simon MC
The Journal of clinical investigation 2003 Jul;112(1):126-35
The Journal of clinical investigation 2003 Jul;112(1):126-35
Stimulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1alpha messenger RNA expression.
Powell JD, Elshtein R, Forest DJ, Palladino MA
Biology of reproduction 2002 Sep;67(3):995-1002
Biology of reproduction 2002 Sep;67(3):995-1002
Putative link between transcriptional regulation of IgM expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the aryl hydrocarbon receptor/dioxin-responsive enhancer signaling pathway.
Sulentic CE, Holsapple MP, Kaminski NE
The Journal of pharmacology and experimental therapeutics 2000 Nov;295(2):705-16
The Journal of pharmacology and experimental therapeutics 2000 Nov;295(2):705-16
Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides.
Palmer LA, Gaston B, Johns RA
Molecular pharmacology 2000 Dec;58(6):1197-203
Molecular pharmacology 2000 Dec;58(6):1197-203
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Supportive validation
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- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
