GZMH

This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]

Description

Granzyme H

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Predicted location

Secreted to blood

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

14 (24606480 - 24609699)

Ensembl ID

ENSG00000100450  (ver. 103.38)

Orthologs

-

UniProt

P20718

neXtProt

NX_P20718

Human splice variants

Protein structure