FAT1

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]

Description

FAT atypical cadherin 1

Tissue specificity

Tissue enhanced (choroid plexus)

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (186587794 - 186726722)

Ensembl ID

ENSG00000083857  (ver. 103.38)

Orthologs

Mouse Fat1: ENSMUSG00000070047

UniProt

Q14517

neXtProt

NX_Q14517

Human splice variants
Mouse splice variants

Protein structure