BS6876

antibody from Bioworld Technology, Inc
Targeting: CDKN1C BWCR, BWS, KIP2, P57
Provider product page for BS6876
Western blot
Immunohistochemistry

Antibody data

Product number
BS6876 - Provider product page
Provider
Bioworld Technology, Inc
Product name
p57/CDKN1C polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human CDKN1C.
Description
p57 / Kip 2 (or CDKN 1C) is a potent tight binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57 / Kip 2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith Wiedemann syndrome (BWS, a cancer syndrome) making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin like growth factor II (IGF II) and H19, both of which seem to be implicated in adrenal neoplasms.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CDKN1C protein structure - BS6876 shown in red.