ODF2

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]

Description

Outer dense fiber of sperm tails 2

Tissue specificity

Tissue enriched (testis)

Subcell location

Vesicles, Centrosome

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (128455186 - 128501292)

Ensembl ID

ENSG00000136811  (ver. 103.38)

Orthologs

Mouse Odf2: ENSMUSG00000026790

UniProt

Q5BJF6

neXtProt

NX_Q5BJF6

Human splice variants
Mouse splice variants

Protein structure