ADAMTS5

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]

Description

ADAM metallopeptidase with thrombospondin type 1 motif 5

Tissue specificity

Tissue enhanced (placenta)

Subcell location

Nucleoplasm

Predicted location

Secreted to extracellular matrix

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

21 (26917922 - 26967088)

Ensembl ID

ENSG00000154736  (ver. 103.38)

Orthologs

Mouse Adamts5: ENSMUSG00000022894

UniProt

Q9UNA0

neXtProt

NX_Q9UNA0

Human splice variants
Mouse splice variants

Protein structure