ARG2

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]

Description

Arginase 2

Tissue specificity

Tissue enhanced (parathyroid gland, prostate, thyroid gland)

Subcell location

Mitochondria

Predicted location

Intracellular

Protein family

Cancer-related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

14 (67619920 - 67651708)

Ensembl ID

ENSG00000081181  (ver. 103.38)

Orthologs

Mouse Arg2: ENSMUSG00000021125

UniProt

P78540

neXtProt

NX_P78540

Human splice variants
Mouse splice variants

Protein structure