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Protein structure
IRF4
Interferon regulatory factor 4LSIRF, MUM1
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
Top validated antibodies |
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| Proteintech Group |  11247-2-AP |
16 references | Polyclonal |
WB
EL
IP
IHC
FC
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| Invitrogen Antibodies | 11247-2-AP |
Polyclonal |
WB
IP
IHC
FC
OA
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| Atlas Antibodies | HPA002038 |
Polyclonal |
WB
IHC
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| NovoPro Bioscience Inc. | 111836 |
Polyclonal |
WB
EL
IP
IHC
FC
|
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| Novus Biologicals | H00003662-M05 |
Monoclonal |
WB
EL
ICC
BN
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