Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
GNB3
G protein subunit beta 3Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]
Top validated antibodies |
|||||
| NSJ Bioreagents |  RQ6637 |
Polyclonal |
WB
EL
ICC
IHC
FC
|
||
| Novus Biologicals | NBP1-52107 |
1 references | Polyclonal |
WB
EL
IHC
|
|
| Biorbyt | orb865523 |
Polyclonal |
WB
EL
ICC
IHC
FC
|
||
| Proteintech Group | 15388-1-AP |
Polyclonal |
WB
EL
ICC
IHC
|
||
| antibodies-online | ABIN569636 |
1 references | Polyclonal |
WB
EL
IHC
|
|
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive) Recommended by provider