PREX1

The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]

Description

Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1

Tissue specificity

Tissue enhanced (bone marrow, brain)

Subcell location

Vesicles, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

20 (48624252 - 48827999)

Ensembl ID

ENSG00000124126  (ver. 103.38)

Orthologs

Mouse Prex1: ENSMUSG00000039621

UniProt

Q8TCU6

neXtProt

NX_Q8TCU6

Human splice variants
Mouse splice variants

Protein structure