IGFBP2

The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]

Description

Insulin like growth factor binding protein 2

Tissue specificity

Tissue enhanced (pancreas)

Subcell location

Endoplasmic reticulum

Predicted location

Intracellular, Secreted to blood

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

2 (216632828 - 216664436)

Ensembl ID

ENSG00000115457  (ver. 103.38)

Orthologs

Mouse Igfbp2: ENSMUSG00000039323

UniProt

P18065

neXtProt

NX_P18065

Human splice variants
Mouse splice variants

Protein structure