ASB7

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Description

Ankyrin repeat and SOCS box containing 7

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Golgi apparatus, Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

15 (100602589 - 100651701)

Ensembl ID

ENSG00000183475  (ver. 103.38)

Orthologs

Mouse Asb7: ENSMUSG00000030509

UniProt

Q9H672

neXtProt

NX_Q9H672

Human splice variants
Mouse splice variants

Protein structure