ESR2

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]

Description

Estrogen receptor 2

Tissue specificity

Tissue enhanced (adrenal gland)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Chromosome

14 (64084232 - 64338112)

Ensembl ID

ENSG00000140009  (ver. 103.38)

Orthologs

Mouse Esr2: ENSMUSG00000021055

UniProt

Q92731

neXtProt

NX_Q92731

Human splice variants
Mouse splice variants

Protein structure