NPY

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

Description

Neuropeptide Y

Tissue specificity

Group enriched (adrenal gland, brain, prostate)

Subcell location

Golgi apparatus

Predicted location

Secreted to blood

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

7 (24284188 - 24291862)

Ensembl ID

ENSG00000122585  (ver. 103.38)

Orthologs

Mouse Npy: ENSMUSG00000029819

UniProt

P01303

neXtProt

NX_P01303

Human splice variants
Mouse splice variants

Protein structure