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AFP
Alpha fetoproteinFETA, HPAFP
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and with teratoma, and has prognostic value for managing advanced gastric cancer. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Oct 2019]
Top validated antibodies |
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| Novus Biologicals |  H00000174-M01 |
4 references | Monoclonal |
WB
EL
ICC
IP
IHC
FA
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| Proteintech Group | 14550-1-AP |
101 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| antibodies-online | ABIN394088 |
5 references | Monoclonal |
WB
EL
ICC
IP
IHC
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| Invitrogen Antibodies | PA5-16658 |
4 references | Polyclonal |
WB
ICC
IHC
FC
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| Abnova Corporation | H00000174-M01 |
2 references | Monoclonal |
WB
EL
ICC
IP
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