LALBA

This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]

Description

Lactalbumin alpha

Tissue specificity

Tissue enriched (breast)

Predicted location

Secreted in female reproductive system

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted secreted proteins

Chromosome

12 (48567684 - 48570066)

Ensembl ID

ENSG00000167531  (ver. 103.38)

Orthologs

Mouse Lalba: ENSMUSG00000022991

UniProt

P00709

neXtProt

NX_P00709

Human splice variants
Mouse splice variants

Protein structure