HRC

This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008]

Description

Histidine rich calcium binding protein

Tissue specificity

Group enriched (heart muscle, skeletal muscle, tongue)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (49151198 - 49155396)

Ensembl ID

ENSG00000130528  (ver. 103.38)

Orthologs

Mouse Hrc: ENSMUSG00000038239

UniProt

P23327

neXtProt

NX_P23327

Human splice variants
Mouse splice variants

Protein structure