KEAP1

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Kelch like ECH associated protein 1

Tissue specificity

Tissue enhanced (skeletal muscle)

Subcell location

Nucleoplasm, Centriolar satellite, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (10486125 - 10503558)

Ensembl ID

ENSG00000079999  (ver. 103.38)

Orthologs

Mouse Keap1: ENSMUSG00000003308

UniProt

Q14145

neXtProt

NX_Q14145

Human splice variants
Mouse splice variants

Protein structure