Tissue expression
Cell line expression
Protein structure
SNCA
Synuclein alphaNACP, PARK1, PARK4, PD1
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Top validated antibodies |
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Invitrogen Antibodies | ![]() |
22 references | Monoclonal |
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Proteintech Group | ![]() |
63 references | Polyclonal |
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Novus Biologicals | ![]() |
1 references | Monoclonal |
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antibodies-online | ![]() |
2 references | Monoclonal |
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R&D Systems | ![]() |
2 references | Polyclonal |
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