CPSF1

Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]). [supplied by OMIM, Mar 2008]

Description

Cleavage and polyadenylation specific factor 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8 (144393229 - 144409335)

Ensembl ID

ENSG00000071894  (ver. 103.38)

Orthologs

Mouse Cpsf1: ENSMUSG00000034022

UniProt

Q10570

neXtProt

NX_Q10570

Human splice variants
Mouse splice variants

Protein structure