RARG

This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Description

Retinoic acid receptor gamma

Tissue specificity

Tissue enhanced (esophagus, skin)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Cancer-related genes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Nuclear receptors
Plasma proteins
Predicted intracellular proteins
Transcription factors

Chromosome

12 (53210567 - 53232980)

Ensembl ID

ENSG00000172819  (ver. 103.38)

Orthologs

Mouse Rarg: ENSMUSG00000001288

UniProt

P13631

neXtProt

NX_P13631

Human splice variants
Mouse splice variants

Protein structure