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Cell line expression
Protein structure
GLUD1
Glutamate dehydrogenase 1GDH, GLUD
This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016]
Top validated antibodies |
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| Invitrogen Antibodies |  PA5-28301 |
2 references | Polyclonal |
WB
EL
ICC
IHC
OA
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| GeneTex | GTX105765 |
3 references | Polyclonal |
WB
EL
ICC
IHC
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| Novus Biologicals | NBP2-16679 |
3 references | Polyclonal |
WB
EL
ICC
IHC
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| NSJ Bioreagents | RQ7175 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| LSBio | LS-C349320 |
Polyclonal |
WB
IHC
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