PPP1R3C

This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016]

Description

Protein phosphatase 1 regulatory subunit 3C

Tissue specificity

Tissue enhanced (skeletal muscle, tongue)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins

Chromosome

10 (91628442 - 91633071)

Ensembl ID

ENSG00000119938  (ver. 103.38)

Orthologs

Mouse Ppp1r3c: ENSMUSG00000067279

UniProt

Q9UQK1

neXtProt

NX_Q9UQK1

Human splice variants
Mouse splice variants

Protein structure