AADAT

This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Description

Aminoadipate aminotransferase

Tissue specificity

Tissue enriched (liver)

Subcell location

Vesicles, Plasma membrane

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (170060222 - 170091699)

Ensembl ID

ENSG00000109576  (ver. 103.38)

Orthologs

Mouse Aadat: ENSMUSG00000057228

UniProt

Q8N5Z0

neXtProt

NX_Q8N5Z0

Human splice variants
Mouse splice variants

Protein structure