HTR3A

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Description

5-hydroxytryptamine receptor 3A

Tissue specificity

Tissue enhanced (lymphoid tissue, pancreas, salivary gland)

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

11 (113974881 - 113990313)

Ensembl ID

ENSG00000166736  (ver. 103.38)

Orthologs

Mouse Htr3a: ENSMUSG00000032269

UniProt

P46098

neXtProt

NX_P46098

Human splice variants
Mouse splice variants

Protein structure