RAD51C

This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Description

RAD51 paralog C

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Vesicles, Cell Junctions, Mitochondria, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (58692573 - 58735611)

Ensembl ID

ENSG00000108384  (ver. 103.38)

Orthologs

Mouse Rad51c: ENSMUSG00000007646

UniProt

O43502

neXtProt

NX_O43502

Human splice variants
Mouse splice variants

Protein structure