Tissue expression
Cell line expression
Protein structure
ACVR2A
Activin A receptor type 2AACTRII, ACVR2
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
Top validated antibodies |
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R&D Systems | ![]() |
6 references | Polyclonal |
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Novus Biologicals | ![]() |
6 references | Polyclonal |
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Invitrogen Antibodies | ![]() |
Polyclonal |
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antibodies-online | ![]() |
5 references | Polyclonal |
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Abnova Corporation | ![]() |
4 references | Polyclonal |
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