ACSL3

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Acyl-CoA synthetase long chain family member 3

Tissue specificity

Tissue enhanced (parathyroid gland)

Subcell location

Nucleoli, Nucleoli rim, Lipid droplets

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (222860942 - 222944639)

Ensembl ID

ENSG00000123983  (ver. 103.38)

Orthologs

Mouse Acsl3: ENSMUSG00000032883

UniProt

O95573

neXtProt

NX_O95573

Human splice variants
Mouse splice variants

Protein structure