KCNA10

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]

Description

Potassium voltage-gated channel subfamily A member 10

Tissue specificity

Not detected

Subcell location

Nucleoplasm, Cytosol

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Voltage-gated ion channels

Chromosome

1 (110517217 - 110519175)

Ensembl ID

ENSG00000143105  (ver. 103.38)

Orthologs

Mouse Kcna10: ENSMUSG00000042861

UniProt

Q16322

neXtProt

NX_Q16322

Human splice variants
Mouse splice variants

Protein structure