Tissue expression
Cell line expression
Protein structure
UVRAG
UV radiation resistance associatedVPS38
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
Novus Biologicals | ![]() |
2 references | Polyclonal |
|
|
antibodies-online | ![]() |
1 references | Polyclonal |
|
|
Proteintech Group | ![]() |
4 references | Polyclonal |
|
|
GeneTex | ![]() |
Polyclonal |
|
||
Invitrogen Antibodies | ![]() |
Polyclonal |
|