ITPKA

Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. [provided by RefSeq, Apr 2011]

Description

Inositol-trisphosphate 3-kinase A

Tissue specificity

Tissue enhanced (brain, intestine)

Subcell location

Vesicles, Plasma membrane

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (41493393 - 41503551)

Ensembl ID

ENSG00000137825  (ver. 103.38)

Orthologs

Mouse Itpka: ENSMUSG00000027296

UniProt

P23677

neXtProt

NX_P23677

Human splice variants
Mouse splice variants

Protein structure