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Cell line expression
Protein structure
CRLF2
Cytokine receptor like factor 2CRL2, TSLPR
This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Top validated antibodies |
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| Novus Biologicals |  AF981 |
4 references | Polyclonal |
WB
ICC
IHC
BN
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| R&D Systems | AF981 |
4 references | Polyclonal |
WB
ICC
IHC
BN
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| Invitrogen Antibodies | 14-5499-82 |
5 references | Monoclonal |
WB
FC
OA
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| antibodies-online | ABIN501083 |
4 references | Polyclonal |
WB
EL
IHC
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| GeneTex | GTX85052 |
Polyclonal |
WB
EL
ICC
IHC
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