KLRC1

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]

Description

Killer cell lectin like receptor C1

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

12 (10442264 - 10454685)

Ensembl ID

ENSG00000134545  (ver. 103.38)

Orthologs

-

UniProt

P26715

neXtProt

NX_P26715

Human splice variants

Protein structure