CD207

The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]

Description

CD207 molecule

Tissue specificity

Tissue enriched (skin)

Subcell location

Cytosol

Predicted location

Membrane

Protein family

CD markers
Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

2 (70830211 - 70835816)

Ensembl ID

ENSG00000116031  (ver. 103.38)

Orthologs

Mouse Cd207: ENSMUSG00000034783

UniProt

Q9UJ71

neXtProt

NX_Q9UJ71

Human splice variants
Mouse splice variants

Protein structure