AKR1C2

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Description

Aldo-keto reductase family 1 member C2

Tissue specificity

Tissue enhanced (adipose tissue, liver, skeletal muscle)

Subcell location

Nucleoplasm, Nucleoli fibrillar center, Endoplasmic reticulum, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (4987400 - 5018031)

Ensembl ID

ENSG00000151632  (ver. 103.38)

Orthologs

-

UniProt

P52895

neXtProt

NX_P52895

Human splice variants

Protein structure