TBCA

The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Description

Tubulin folding cofactor A

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli, Microtubules

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (77691166 - 77868780)

Ensembl ID

ENSG00000171530  (ver. 103.38)

Orthologs

Mouse Tbca: ENSMUSG00000042043

UniProt

O75347

neXtProt

NX_O75347

Human splice variants
Mouse splice variants

Protein structure