PIK3R5

Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]

Description

Phosphoinositide-3-kinase regulatory subunit 5

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Centriolar satellite, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

17 (8878911 - 8965712)

Ensembl ID

ENSG00000141506  (ver. 103.38)

Orthologs

Mouse Pik3r5: ENSMUSG00000020901

UniProt

Q8WYR1

neXtProt

NX_Q8WYR1

Human splice variants
Mouse splice variants

Protein structure