Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
ETV1
ETS variant transcription factor 1ER81
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]
Top validated antibodies |
|||||
| Invitrogen Antibodies |  PA5-41484 |
4 references | Polyclonal |
WB
IHC
OA
|
|
| GeneTex | GTX129202 |
Polyclonal |
WB
ICC
IHC
|
||
| LSBio | LS-C197163 |
Monoclonal |
WB
EL
|
||
| Biorbyt | orb1010245 |
Polyclonal |
WB
EL
ICC
IHC
|
||
| Boster Biological Technology | A01383 |
Polyclonal |
WB
EL
IHC
|
||
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider