IL11RA

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

Description

Interleukin 11 receptor subunit alpha

Tissue specificity

Low tissue specificity

Predicted location

Membrane, Secreted to blood

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Predicted secreted proteins

Chromosome

9 (34650702 - 34661902)

Ensembl ID

ENSG00000137070  (ver. 103.38)

Orthologs

-

UniProt

Q14626

neXtProt

NX_Q14626

Human splice variants

Protein structure