SRA1

Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]

Description

Steroid receptor RNA activator 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Microtubules, Cytokinetic bridge, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

5 (140537340 - 140558252)

Ensembl ID

ENSG00000213523  (ver. 103.38)

Orthologs

Mouse Sra1: ENSMUSG00000006050

UniProt

Q9HD15

neXtProt

NX_Q9HD15

Human splice variants
Mouse splice variants

Protein structure